Rapid Revision: All Facts About Ethinylestradiol - OnePharmily OnePharmily: Rapid Revision: All Facts About Ethinylestradiol
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Tuesday, 23 October 2018

Rapid Revision: All Facts About Ethinylestradiol


Fact 1: Ethinylestradiol is used widely in birth control pills, often alongside progestins.

Fact 2: It may also be used as part of a wider menopausal hormone therapy plan to treat symptoms.

Fact 3: The drug can be administered orally, by transdermal patch and via a vaginal ring.

Fact 4: It was first introduced for medical use in 1943.

Fact 5: Mechanism of action -
# Ethinylestradiol works in conjunction with a progestin by suppressing LH/FSH release to prevent ovulation.
# Luteinising hormone (LH) and follicle
stimulating hormone (FSH) are responsible for ovulation and ovarian synthesis of estrogen and progesterone.

Fact 6: Avoid in pregnancy. Avoid in patients with breast cancer and in patients with an increased risk of developing VTE or cardiovascular
disease.

Fact 7: CYP3A4 inducers such as phenytoin, rifampin and fluconazole decrease its efficacy.

Fact 8: side effects include -
Irregular bleeding
Mood changes
Venous thromboembolism
Breast tenderness
Headache
Nausea
Fluid retention
Cholestatic hepatotoxicity
Inc. risk of endometrial cancer

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